Which of the following medications is NOT associated with involuntary weight loss?

The correct choice is diuretics, as they are primarily used to promote the excretion of excess fluid in conditions such as hypertension and heart failure. Diuretics do not typically cause involuntary weight loss through mechanisms such as appetite suppression or metabolic changes. Instead, any changes in body weight associated with diuretics usually result from fluid shifts rather than true weight loss from body tissue or fat stores.

Involuntary weight loss can be a significant concern in older adults, for whom maintaining nutritional status is crucial. Other medications, like benzodiazepines and certain antibiotics, might contribute to decreased appetite, increased metabolic rate, or gastrointestinal disturbances, leading to weight loss. Digoxin, primarily used to treat heart conditions, can also lead to nausea and a resultant decrease in food intake, potentially contributing to weight loss. Understanding the side effects of various medications is vital, especially when managing the health and nutritional needs of older adults.