Which of the following is a sign of pyridoxine deficiency?

Pyridoxine, or vitamin B6, plays a crucial role in numerous physiological functions, including the metabolism of proteins, carbohydrates, and fats, as well as in the synthesis of neurotransmitters. A deficiency in pyridoxine can manifest through a variety of signs and symptoms, one of the most notable being scaliness of the skin and peripheral neuropathy.

Scaliness indicates a disrupted skin barrier and can be a direct result of insufficient pyridoxine, as it is involved in maintaining healthy skin. Peripheral neuropathy, characterized by symptoms such as numbness, tingling, or pain in the extremities, also occurs due to the role of vitamin B6 in nerve function and health. This dual presentation of skin and neurological issues is strongly associated with pyridoxine deficiency.

On the other hand, the symptoms listed in the other options pertain to deficiencies in different vitamins or may represent conditions that are not exclusively related to vitamin B6. For instance, night blindness and dry membranes are more commonly indicative of vitamin A deficiency, while hyperpigmentation and skin flushing are not specific to any particular vitamin deficiency but may arise from various dermatological conditions or nutritional imbalances. Therefore, the presence of scaliness and peripheral neurop