What medication is known to increase triglyceride levels?

Clofibrate is known to be a fibrate medication that is actually used to lower triglyceride levels, making this choice incorrect. Statins are primarily known for lowering cholesterol levels; while they might have a modest effect on triglycerides, they are not typically associated with a significant increase in triglyceride levels, so this choice is also not applicable.

Ascorbic Acid, or vitamin C, does not have any known effect on significantly raising triglyceride levels. It is primarily an antioxidant and plays a role in various metabolic processes but is not linked to triglyceride elevation.

Cholestyramine, a bile acid sequestrant, is used to lower cholesterol levels by preventing its reabsorption in the intestines. However, in some individuals, particularly when dosages are not optimized or in cases where the body compensates by mobilizing fatty acids, cholestyramine can lead to increased triglyceride levels as a side effect. This makes it the correct choice when considering medications known to potentially raise triglycerides in certain patient scenarios.