What lab values are usually normal in megaloblastic anemia?

In megaloblastic anemia, certain lab values can give insight into the condition. The correct answer highlights that mean corpuscular hemoglobin concentration (MCHC) and low or normal serum vitamin B12 levels typically present in megaloblastic anemia.

Megaloblastic anemia is often associated with deficiencies in vitamin B12 or folate, which lead to ineffective red blood cell production. The presence of low or normal serum vitamin B12 levels may occur when there is a functional deficiency despite adequate intake due to factors like malabsorption or specific conditions impacting metabolism. MCHC, which reflects the concentration of hemoglobin in red blood cells, may remain within the normal range in this type of anemia depending on the individual’s other health factors and compensatory mechanisms.

This explanation accurately reflects the characteristics of megaloblastic anemia and why those specific lab values are relevant in its diagnosis and understanding. The other choices present scenarios that do not align as closely with the common lab values observed in megaloblastic anemia. For instance, high or normal serum vitamin B12 levels generally indicate there is no deficiency, which contradicts the underlying issue in megaloblastic anemia.