What lab values are elevated in pernicious anemia?

In pernicious anemia, the lab values that are typically elevated include MCV (Mean Corpuscular Volume) and Homocysteine. Pernicious anemia is primarily caused by an inability to absorb vitamin B12 due to a lack of intrinsic factor, which can lead to macrocytic anemia characterized by larger-than-normal red blood cells. Therefore, MCV values are elevated as the individual’s body produces fewer but larger red blood cells.

Homocysteine levels can also become elevated because vitamin B12 is necessary for converting homocysteine into methionine. Without adequate vitamin B12, this conversion process is impaired, leading to an accumulation of homocysteine in the blood.

While values like transferrin and folate may reflect other processes in the body, they are not definitive indicators of pernicious anemia in terms of elevation directly related to this condition. Thus, the combination of elevated MCV and homocysteine specifically aligns with the pathophysiology of pernicious anemia.