What are clinical signs of Cachexia?

Cachexia is a complex metabolic syndrome associated with an underlying illness, characterized by a loss of muscle mass, fat loss, and significant weight loss. It is particularly common in chronic diseases such as cancer, chronic obstructive pulmonary disease (COPD), and heart failure.

The clinical signs of cachexia encompass a range of symptoms that reflect this multifaceted condition. Anorexia, which is a reduced appetite or desire to eat, and fat depletion are key contributors to weight loss and muscle atrophy. This indicates that nutritional intake is insufficient, leading to the breakdown of body tissues for energy, which aligns with the definition of cachexia.

Early satiety, where a person feels full after eating only a small amount of food, can also be a manifestation of cachexia. This often results from changes in digestive physiology and psychological factors, further limiting food intake and exacerbating weight loss.

Muscle protein breakdown is a critical sign of cachexia and highlights the significant muscle wasting that occurs in this syndrome. This process not only contributes to the loss of lean body mass but also impacts physical function and overall health. The decline in attention span can be associated with nutritional deficiencies and the overall physical state of individuals experiencing cachexia, indicating the broader systemic effects of the condition beyond