In the context of hepatic disease, which of the following should be monitored for potential deficiency?

Monitoring Vitamin D levels in the context of hepatic disease is particularly important due to the liver's role in vitamin metabolism. The liver is responsible for the hydroxylation process needed to convert vitamin D into its active form, calcitriol. In patients with hepatic disease, this biochemical conversion may be impaired, leading to a deficiency in active vitamin D. A deficiency in vitamin D can result in several health issues, including complications such as bone disorders and impaired calcium regulation.

While other vitamins and minerals may also be affected in the context of liver disease, Vitamin D's unique reliance on liver function for its activation makes it a critical nutrient to monitor. In contrast, Vitamin C and Calcium are less directly affected by liver function in terms of their absorption and utilization, and Vitamin A, although important, is often not as closely linked to hepatic function as Vitamin D. In summary, monitoring Vitamin D levels in patients with hepatic disease is essential due to the liver's pivotal role in its activation and the potential health risks associated with deficiency.